Everyone is different. Each of us have subtle genetic variations that manifest themselves in the varied responses that can be experienced in reaction to a drug. Many of these “side effects” can be traced to variability in how the liver processes a drug molecule. Idiosyncratic drug-induced liver injury encompasses the unexpected harms that prescription and non-prescription drugs, herbal and dietary supplements may cause to the liver. This issue is compounded by the inadvertent combination of active molecules in individuals with multiple prescriptions or self-prescribing. Trying to understand these effects is hamstrung by the lack of tissue models which are capable of recapitulating the varied responses experienced in the liver. As such, this issue remains a major public health challenge and a major cause of drug attrition.
This project will build from the work of the halt-RONIN (https://halt-ronin.com) consortium to engineer new models to study mechanisms of idiosyncrasy, to define biomarkers for its prediction and early diagnosis, and to improve the process of drug development. During your PhD, you’ll become expert in the design and engineering of modifications to liver cells, their culture into 3D tissue analogues and the development of assays able to interrogate their behaviour.
For further information please contact Prof. Alistair Elfick.
Further Information:
The University of Edinburgh is committed to equality of opportunity for all its staff and students, and promotes a culture of inclusivity. Please see details here: https://www.ed.ac.uk/equality-diversity
Closing Date:
Principal Supervisor:
Assistant Supervisor:
Dr Lenny Nelson
Eligibility:
Minimum entry qualification - an Honours degree at 2:1 or above (or International equivalent) in a relevant science or engineering discipline, possibly supported by an MSc Degree. Further information on English language requirements for EU/Overseas applicants.
Funding:
Applications are welcomed from self-funded students, or students who are applying for scholarships from the University of Edinburgh or elsewhere.
