Research Ethics and Integrity at the School of Engineering
School Requirement
The School requires that all research carried out by its members is of the highest scientific and ethical standards, and follows the University's guidelines:
Knee osteoarthritis (OA) is a common degenerative joint disease affecting 12% of the over 60s symptomatically. In approximately 20% of cases this is isolated to the medial compartment of the knee and could be managed with unicompartmental knee replacement (UKR) rather than total knee replacement (TKR). However, the survivorship of UKRs is globally inferior to that of TKRs. Unexplained pain is the second commonest cause for revision of UKR, but this is not the case with TKRs. We hypothesised that elevated proximal tibial strain under medial UKR implants may be a cause of this unexplained pain. The aims of this study are therefore to determine the effect of medial UKR tibial component design on proximal tibial strain and pain.
The development of 3-dimensional implantable liver organoids, with the aim of providing alternative renewable solutions to organ transplantation in the treatment of human liver disease.
