The need for information and communication technology superiority is central to defence and security. We focus on solving significant, enduring challenges, such as pervasive intelligence, surveillance, and reconnaissance (ISR) across multiple sensing domains, reliable communications, and creating capability that is affordable, survivable, and responsive to rapidly evolving threats in electromagnetically denied environments. This will be increasingly underpinned by interconnected technology and sensing modalities, leveraging advances in autonomy, embedded systems, and AI. The family of interconnected technologies covered by SPADS, from sensing to knowledge and autonomous systems, spans the key tasks of sensing, processing and communications across both software/algorithms and hardware, covering both discovery and mission-inspired research.Each component further subdivides into areas such as sensor hardware, fabrication and integration, machine learning (ML) and symbolic AI algorithms, sensory fusion architectures, autonomous agent design, human-machine cooperation techniques, low-power architectures, computing-at-the-edge, secure-by-design hardware, nanotechnology and emerging (beyond CMOS) electronics.The SPADS theme structure is designed to:encourage interconnection and collaboration between themes.collectively form a complete basis for creating end-to-end AI-powered systems.Ultimately, we want our students to collectively design cutting-edge, physically embodied systems (i.e. hardware-implemented) capable of simultaneously sensing and computing with: (i) smooth integration between sensing and computation, (ii) modular design principles, and (iii) a competitive edge in functionality, Size, Weight And Power (SWAP) or both when physically deployed in the field.SPADS will provide world-class training for students with the breadth and depth of expertise needed to innovate generation-after-next technology crucial to these challenges, gain practical experience, and provide a skills-programmes to increase UK talent in critical areas.Impact Beyond Defence While focused on national security, the technologies developed in SPADS have a substantial broader impact. These advances in low-power distributed sensing and autonomous applications are crucial for fields like environmental monitoring, emergency response, home health monitoring, and automated warehousing. Autonomous Sensing Platforms Developing resilient autonomous multi-sensor sensing platforms for dynamic, challenging environments Multi-agent Systems and Data Intelligence Developing new algorithms for efficient and scalable coordination of multi-agent systems Novel Computing and Beyond CMOS Hardware Building novel architectures: leveraging next-generation micro/nano-electronics for high-performance, low-SWAP systems Sensor Signal Processing Transforming sensor data into actionable intelligence for superior decision-making This article was published on 2025-10-31