Mechanical Engineering

This PhD project proposes an innovative exploration of how sex-specific differences in hormonal profiles and blood flow dynamics impact liver function, utilizing cutting-edge techniques involving liver organoids and microfluidic technology. Males and females differ significantly in their liver function and pathology, thought to be largely due to variations in hormonal environment and hemodynamics. Despite these observations, current approaches to elucidating these effects are limited, and rely heavily on expensive, time-consuming, and ethically challenging animal models and clinical trials. This project aims to fill this critical gap by developing and leveraging organoid-based models coupled with microfluidic systems to simulate and study the effects of these variables on liver behavior.

The overarching aims of the project will be:

1. Develop and Characterize Sex-Specific Liver Organoids: Generate male and female liver organoids using cells derived from human pluripotent stem cells. These organoids will provide a 3D cellular architecture that mimics the microenvironment of the human liver.
2. Integrate Liver Organoids into a Microfluidic Platform: Deploy these organoids within a microfluidic device designed to mimic blood flow characteristics. This integration will allow for the precise control and measurement of fluid shear stress and oscillating hormone profiles, mimicking the physiological conditions of male and female circulatory systems.
3. Investigate Hormonal Impact: Examine how exposure to different levels and types of hormones, such as estrogen and testosterone, influences liver function within this controlled setting. Focus will be on key functional metrics like metabolism, bile production, and response to injury.

The project aims to reveal critical insights into the sex-specific regulatory mechanisms of liver function influenced by hormonal and hemodynamic conditions. By elucidating these differences, the research will contribute to a more nuanced understanding of liver disease pathogenesis across sexes, potentially guiding more personalized medical treatments.

Location and skills: The project will be carried out at the Institute for Bioengineering (IBioE) at the University of Edinburgh. The student will attain skills in mammalian cell culture, microfluidics, materials, optical microscopy, as well as data and image analysis.

Career development -

Institutional and Peer Support: you will benefit from an excellent supportive environment at the School of Engineering within the Institute for Bioengineering at The University of Edinburgh.

International Collaboration: the successful student will also have to opportunity visit and interact with our network of international collaborators.

Impactful publications and dissemination: the student will also benefit from strong support towards publications in world class journals and participation in major conferences as well as support to undertake outreach to the wider public.

Teaching and Research Development: the potential student will have the opportunity (once trained and familiar with relevant materials) to become a teaching assistant for courses offered at the School of Engineering.

The University of Edinburgh is committed to equality of opportunity for all its staff and students, and promotes a culture of inclusivity. Please see details here: https://www.ed.ac.uk/equality-diversity

Applicants applying for an MRC DTP in Precision Medicine studentship must have obtained, or will soon obtain, a first or upper-second class UK honours degree or equivalent non-UK qualification, in an appropriate science/technology area.

Further information on English language requirements for EU/Overseas applicants.

We welcome applications from self-funded students

Further information and other funding options.

Membrane-based processes for water treatment, such as reverse osmosis (RO), hold promise in tackling water scarcity locally and globally. Nevertheless, conventional polyamide membranes for RO exhibit low rejection of Small, charge-Neutral Contaminants (SNCs), which endanger human health and biota.

Progress towards highly selective membranes has been hindered by insufficient understanding of the mechanisms that underlie separation efficiency: how water and contaminants sorb into, and diffuse through, polyamide membranes. Both contaminant sorption and transport require a molecular-level treatment, at far higher resolution than is afforded by conventional (continuum) membrane transport models.

Using molecular dynamics (MD) simulation and free energy calculations, this project aims to computationally design highly selective RO membranes by elucidating the mechanisms governing SNC sorption and transport. The project will focus on SNCs that are insufficiently rejected by state-of-the art RO membranes, e.g., boric acid, a toxic constituent of seawater, and N-nitrosodimethylamine (NDMA), a carcinogenic disinfection by-product whose insufficient removal during RO-based wastewater reuse (rejection ~ 60%) demands additional, and costly, advanced oxidation processes (e.g., high-energy UV).

The specific objectives of this project are:

• Objective 1. To gain molecular-level insight into the hydration layer at the polyamide-water interface, to understand how interfacial water molecules determine SNC sorption and transport.
• Objective 2. To elucidate the role of interfacial chemistry in SNC sorption to polyamide, in order to computationally develop surface coatings to bolster SNC rejection, and thus establish structure-property-performance relations linking coating composition with SNC rejection.
• Objective 3. To characterise the transport mechanisms of SNCs through polyamide, to enable transport models to quantify the trade-off between contaminant rejection and water permeance.

Simulation insights emerging from this project will enable membrane manufacturers to develop highly selective RO membranes. These materials will lower the cost of seawater desalination and wastewater recycling by RO, in addition to producing safer product water for humans and ecosystems.

Research and Training

The successful applicant will conduct research in the School of Engineering at the University of Edinburgh, under the co-supervision of Dr Santiago Romero-Vargas Castrillón and Dr Rohit Pillai. The student will have access to a wide range of computational facilities, including ARCHER2, the UK’s national supercomputer. Educational and research opportunities afforded by this project include:

• Training in state-of-the-art molecular simulation technique
• Close mentoring through regular meetings, as well as interactions with other investigators at the Institute of Multiscale Thermofluids (IMT) and the Institute for Infrastructure and Environment (IIE) at Edinburgh
• The opportunity to attend national and international scientific conferences to disseminate your result
• Strong emphasis and support to publish research results in leading scientific journals, which will kickstart your career in academia or industry

The University of Edinburgh is committed to equality of opportunity for all its staff and students, and promotes a culture of inclusivity. Please see details here: https://www.ed.ac.uk/equality-diversity

This is a challenging and scientifically ambitious project, requiring a student who is dedicated and enthusiastic about asking, and tackling, fundamental questions. The successful applicant will have been awarded an undergraduate degree at the time of appointment (2:1 or above, preferably supported by an MSc) in chemical engineering, mechanical engineering, chemistry, physics, materials science, or a cognate field. A strong background in mathematics and physics is required, as well as interest in molecular simulation. Prior research experience in modeling and simulation is highly desirable.

Further information on English language requirements for EU/Overseas applicants.

Applications are welcomed from self-funded students, or students who are applying for scholarships from the University of Edinburgh or elsewhere, as explained below.

PhD studentships managed by the School of Engineering at the University of Edinburgh are available every year through a competitive process.

Applicants interested in applying for a University-administered award should e-mail the supervisors (Santiago@ed.ac.uk, R.Pillai@ed.ac.uk) as soon as possible to begin discussions, explaining how your experience meets the Applicant Requirements given above. Application deadlines vary from mid-January to late March.

Please note that most studentships are available only to Home Students (International students not eligible.)

To qualify as a Home student, you must fulfil one of the following criteria:

• You are a UK student

• You are an EU student with settled/pre-settled status who also has 3 years residency in the UK/EEA/Gibraltar/Switzerland immediately before the start of your Programme.

Further information and other funding options.

Condensation is a heat transfer process in which a vapor releases energy/heat as it changes its phase to become a liquid, which typically occurs when the vapor is cooled below its dew temperature, often upon making contact with a cooler surface. This process is critical in numerous applications, including in HVAC systems, power generation, and refrigeration. The effectiveness of dropwise condensation in transferring heat makes it essential in condensers, where minimizing the surface area for dropwise condensation and optimizing conditions for heat transfer can significantly enhance system efficiency. Techniques such as enhancing surface properties or controlling fluid dynamics are often employed to maximize the rate of heat transfer during the condensation process.

Recently, we developed new techniques to modify surfaces with regions that can tune the surface properties and control the fluid dynamics of condensing droplets via patterned liquid-like surfaces, which are based on Slippery Covalently Attached Liquid-like Surfaces (SCALS). In this experimental project, you will tackle questions involving condensation on patterned liquid-like surfaces: we are interested in understanding how the different SCALS chemistries and the nature of the patterning affect condensation and heat transfer and help to maintain a stable heat flux during condensation phase-changes. This will require parametric and methodological studies and by answering questions like these, you will be pushing the boundaries of knowledge in this field and kick-start your postgraduate career.

We expect that you will have a good degree in Engineering or Physics with an experimental and modelling background. We are particularly interested to hear from applicants with experience in surface science, fluids dynamics and fluid mechanics and/or phase change.

If successful, you will become a member of the Wetting, Interfacial Sciences and Engineering WISE Group within the Institute for Multiscale Thermofluids at the School of Engineering. You will join a vibrant community of PhD students, postdoctoral research associates and academics working in various aspects of surfaces and wetting, and will develop as a scientist benefiting from our track record, which includes publications in top journals, international collaborations and contributions to key international conferences.

The University of Edinburgh is committed to equality of opportunity for all its staff and students, and promotes a culture of inclusivity: https://www.ed.ac.uk/equality-diversity

Minimum entry qualification - an Honours degree at 2:1 or above (or International equivalent) in Engineering or Physics with an experimental and modelling background, possibly supported by an MSc Degree. We are particularly interested to hear from applicants with experience in surface science, fluids dynamics and fluid mechanics and/or phase change.

Further information on English language requirements for EU/Overseas applicants.

Applications are welcomed from self-funded students, or students who are applying for scholarships from the University of Edinburgh or elsewhere.

Further information and other funding options.

The interaction of droplets with structured surfaces is extremely important in microfluidics, with target applications in medical diagnostics, self-assembly and printing. In this project you will study the dynamic interactions of droplets with structured solid surfaces coated by a thin liquid lubricant layer. Depending on your skills and interests, you will tackle questions about the fluid dynamics of this system using experimental/computational approaches, or a combination of both.

If successful, you will become a member of the Wetting, Interfacial Sciences and Engineering Group within the Institute for Multiscale Thermofluids at the School of Engineering. You will join a vibrant community of PhD students, postdoctoral research associates and academics working in various aspects of surfaces and wetting, and will develop as a scientist benefiting from our track record, which includes publications in top journals, international collaborations and contributions to key international conferences.

Informal queries can be directed to Dr Rodrigo Ledesma-Aguilar (Rodrigo.ledesma@ed.ac.uk)

The University of Edinburgh is committed to equality of opportunity for all its staff and students, and promotes a culture of inclusivity: https://www.ed.ac.uk/equality-diversity

Minimum entry qualification - an Honours degree at 2:1 or above (or International equivalent) in a relevant science or engineering discipline, possibly supported by an MSc Degree.

We expect that you will have a good degree in Engineering or Physics with an experimental or computational modelling background. We are particularly interested to hear from applicants with experience in surfaces and fluid mechanics.

Further information on English language requirements for EU/Overseas applicants.

Applications are welcomed from self-funded students, or students who are applying for scholarships from the University of Edinburgh or elsewhere.

Further information and other funding options.

Friction is a key limiting factor affecting the motion of liquids in contact with solid surfaces. When water droplets interact with a solid surface, friction can severely limit the speed at which they move, or hamper their motion altogether. Fundamentally, friction between droplets and solid forces is an open field of research in fluid mechanics, with important applications in a range of fields, from microfluidics to self-cleaning and heat transfer.  

Recently, we have initiated research on the interaction between droplets and liquid-like surfaces. These are surfaces created by grafting polymer chains to a solid substrate, thus creating an ultrasmooth surface. In this project you will study the dynamics of droplets on patterned LLS, where a surface topography, or a chemical pattern, is applied. The scope of the project will be experimental, theoretical, or a combination of both, depending on your specific skill set. By addressing the questions of this project, you will be pushing the boundaries of knowledge in this new field and kick-start your postgraduate career.

If successful, you will become a member of the Wetting, Interfacial Sciences and Engineering Group within the Institute for Multiscale Thermofluids at the School of Engineering. You will join a vibrant community of PhD students, postdoctoral research associates and academics working in various aspects of surfaces and wetting, and will develop as a scientist benefiting from our track record, which includes publications in top journals, international collaborations and contributions to key international conferences.

The following academic team will be part of your supervision team:

Principal supervisor:
Rodrigo Ledesma Aguilar: https://www.eng.ed.ac.uk/about/people/dr-rodrigo-ledesma-aguilar

Assistant supervisors:
Gary Wells: https://www.eng.ed.ac.uk/about/people/dr-gary-wells
Professor Glen McHale: https://www.eng.ed.ac.uk/about/people/professor-glen-mchale

Informal queries can be directed to Dr Rodrigo Ledesma-Aguilar (Rodrigo.ledesma@ed.ac.uk)

The University of Edinburgh is committed to equality of opportunity for all its staff and students, and promotes a culture of inclusivity: https://www.ed.ac.uk/equality-diversity

Minimum entry qualification - an Honours degree at 2:1 or above (or International equivalent) in a relevant science or engineering discipline, possibly supported by an MSc Degree.

We expect that you will have a good degree in Engineering or Physics with an experimental and/or modelling background. We are particularly interested to hear from applicants with experience in surfaces and fluid mechanics.

Further information on English language requirements for EU/Overseas applicants.

Applications are welcomed from self-funded students, or students who are applying for scholarships from the University of Edinburgh or elsewhere.

Further information and other funding options.

Food texture is related to the way our senses perceive and feel the rheological and mechanical properties of edible substances. For example a potato chip is crispy; an apple is crunchy; butter is soft; bread is firm; candy is hard; yogurt is smooth; cream is thick; cake is moist, and honey is sticky. Food texture is critical for the consumer and impacts on a product’s market share. It is affected by the composition, manufacturing process, storage conditions and aging. It impacts the final quality and nutrition value of the food product. Food industry strives to improve texture while enhancing the product’s nutritional value and health benefits. For example, healthy oleogels can be used in substitution of harmful trans/saturated fats while retaining the sense of a “mouthful” product.

Texture is complex to quantify, as it is the result of interplay of the food mechanical and rheological properties as physically sensed in the mouth. It is the result of the complex movement of chewing involving our jaws, teeth, and tongue, and the combined comminution (particle size distribution change) and gradual dissolution of substances in saliva.

This project aims to develop and combine mechanical and rheological testing methodologies that will characterize texture rapidly and reliably, in real time, during the manufacturing and storage period. The experimental program will be complemented by state-of-the-art artificial intelligence (AI) and machine learning (ML) methodologies in order to correlate improved texture with optimized manufacturing and storage processes.

The ideal candidate will combine strong experimental and computational skills, an interest in food science and engineering, mechanics, rheology and numerical methods/software (e.g., MATLAB, Python).

https://vasileioskoutsos.wixsite.com/softmaterials

www.eng.ed.ac.uk/about/people/dr-dimitrios-i-gerogiorgis

The University of Edinburgh is committed to equality of opportunity for all its staff and students, and promotes a culture of inclusivity. Please see details here: https://www.ed.ac.uk/equality-diversity

An undergraduate degree in Chemical/Mechanical Engineering, or a closely related area (Physics, Chemistry), with a strong background in computational modelling.

Minimum entry qualification - an Honours degree at 2:1 or above (or International equivalent) in a relevant science or engineering discipline, possibly supported by an MSc Degree.

Further information on English language requirements for EU/Overseas applicants.

Applications are welcomed from self-funded students, or students who are applying for scholarships from the University of Edinburgh or elsewhere

Further information and other funding options.

The wetting behaviours of liquids on solid surfaces play an important role for a wide range of engineering applications, including coatings, electronics, oil recovery, microfluidics, and inkjet printing. For many of these applications, the key challenge is to control the static and dynamic wettability of a given substrate against various liquids. To achieve such control, especially over the full range of wettability landscape, surface chemistry, while crucial, is inadequate by itself. Recent works have shown that novel surfaces with exceptional wetting properties (often termed as superwettability) can be designed by introducing roughness, lubrication, chemical heterogeneities, and tuning the elasticity of the substrate.

The underlying theme of this PhD project is to study the rich interplay between fluid flow dynamics, surface chemistry, geometry, roughness, and solid elasticity in the context of wetting phenomena. Depending on the interests of the student, they can focus on modelling or combine modelling and experiments to develop engineering design principles for structured surfaces with superwettability properties. We will consider both model surfaces with regular patterns (e.g., posts, holes) and non-ideal, industrially relevant substrates (e.g., complex fibres, meshes). This project will also involve collaborations with our international experimental and industrial partners, Dr.-Ing. Hutomo Suryo Wasisto (Infineon Technologies AG, Germany) and Prof. Kuwat Triyana (Universitas Gadjah Mada, Indonesia), to explore how these design principles can be exploited for applications in microelectromechanical system (MEMS) and sensor technologies.

It is expected that the applicant will have a good degree in Engineering, Physics, Mathematics, or any other related subject. We are particularly keen to hear from applicants who want to develop expertise in fluids, surfaces, and/or simulations using high performance computing. Prior experience in any of these areas is useful but not a necessity to apply.

The student will join Prof Halim Kusumaatmaja’s group which will move to the Institute for Multiscale Thermofliuds at the University of Edinburgh in May 2024. The student will also benefit from a vibrant community of PhD students, postdoctoral research associates and academics working in various aspects of surfaces and wetting in Edinburgh.

The University of Edinburgh is committed to equality of opportunity for all its staff and students, and promotes a culture of inclusivity. Please see details here: https://www.ed.ac.uk/equality-diversity

Further information about Prof Halim Kusumaatmaja’s group can be found in: https://sites.google.com/site/kusumaatmaja/home 

Minimum entry qualification - an Honours degree at 2:1 or above (or International equivalent) in a relevant science or engineering discipline, possibly supported by an MSc Degree. Further information on English language requirements for EU/Overseas applicants.

Applications are welcomed from self-funded students, or students who are applying for scholarships from the University of Edinburgh or elsewhere.

Further information and other funding options.

This project aims to investigate the capabilities of adaptive structures that change their geometry and mechanical properties to accommodate operational loading and extend their lifespan, thereby supporting sustainable infrastructure and a circular economy.

The core objective of this project is to engineer a self-adapting structure that adjusts to the prescribed loading conditions. This adaptation is achieved by integrating local structures that accommodate stiffness variations along the global structure. The local structures will change their geometry and shape in response to the applied loads, resulting in emergent properties in the main global structure. Analytical modeling of the sub-structures will provide understanding and control for stiffness tailoring, which will translate into desirable mechanical properties in the main structure. The connection between global properties and sub-structure geometry changes aims to be achieved by understanding the relationships between geometric parameters and vibration response. The geometric nonlinearity induced by the local sub-structures may cause amplitude-dependent nonlinear dynamic responses. Thus, understanding the underlying physics in the coupling between local and global structures, along with the vibration response of the global structure, aims to facilitate feedback to passively control the mechanical properties of the structure. Consequently, this dynamic response leads to continuous shape and geometry modifications within the structure, ultimately enhancing its capacity to accommodate specified loading requirements more effectively. The adaptive structures will benefit operability by maximizing structural capacity during service.

This project is supervised by Dr David Garcia Cava (School of Engineering, University of Edinburgh). It will involve regular interaction with collaborators from academia and industry. Interested candidates may contact the supervisor for further information (david.garcia@ed.ac.uk).

Personal website: https://dgarciacava.github.io/

This advert might close once a suitable candidate is found. Please apply as soon as possible to avoid disappointment.

References

[1] Sundararaman, V., O’Donnell, M.P., Chenchiah, I.V., Clancy, G. and Weaver, P.M., 2023. Stiffness tailoring in sinusoidal lattice structures through passive topology morphing using contact connections. Materials & Design, 226, p.111649.

[2] Zhao, B., Thomsen, H.R., Pu, X., Fang, S., Lai, Z., Van Damme, B., Bergamini, A., Chatzi, E. and Colombi, A., 2024. A nonlinear damped metamaterial: Wideband attenuation with nonlinear bandgap and modal dissipation. Mechanical Systems and Signal Processing, 208, p.111079.

The University of Edinburgh is committed to equality of opportunity for all its staff and students, and promotes a culture of inclusivity. Please see details here: https://www.ed.ac.uk/equality-diversity

Minimum entry qualification - an Honours degree at 2:1 or above (or International equivalent) in a relevant science or engineering discipline, possibly supported by an MSc Degree.

Applications are particularly welcome from candidates expecting to receive a first-class degree in mechanical engineering, physics, applied mathematics or a closely related subject.

Interests on: Structural mechanics and dynamics, Stochastic modelling and uncertainty quantification.

Further information on English language requirements for EU/Overseas applicants.

Applications are welcomed from self-funded students, or students who are applying for scholarships from the University of Edinburgh or elsewhere.

*Competition (EPSRC) funding may be available for an exceptional candidate but please note you must be a UK student or an EU student who has pre-settled/settled status and has lived in the UK for at leats 3 years.

Further information and other funding options.