Room 1.03, Scottish Microelectronics Centre, King's Buildings
Seminar by Dr. Stella Pang, City University of Hong Kong, Dept. of Electrical Engineering. Center for Biosystems, Neuroscience, and Nanotechnology,
Highly Sensitive Plasmonic Biosensor and Engineered Topography for Cell Migration Control
Localized surface plasmon resonance (LSPR) effect is applied to distinguish cell concentration on ordered arrays of Au nanoparticles (NPs) formed by nanosphere lithography. Human-derived retinal pigment epithelial RPE-1 cells with flatter bodies and higher confluency will be compared with breast cancer MCF-7 cells. We find that optimal cell sensing could be achieved by altering the dimensions of Au NPs and their layer structures according to different cell characteristics and concentrations.
In addition, the effects of surface topography on the migration of adherent cells will be demonstrated. We have developed patterns in polydimethylsiloxane (PDMS) that can influence the direction of cell migration. The results indicate that cell migration directionality could be controlled by the designed patterns such as square arrays, gratings, and connected arcs with different degrees of rotational symmetry. The engineered cell culture platforms are found to consistently induce changes in the directional persistence and migration speed of adherent cells.
Stella W. Pang joined the City University of Hong Kong as Chair Professor in the department of Electronic Engineering in 2012. She is the director of Center for Biosystems, Neuroscience, and Nanotechnology. Previously, she was Professor of Electrical Engineering and Computer Science at the University of Michigan from 1990 to 2011. She served as the Associate Dean for Graduate Education and International Programs in the College of Engineering from 2002 to 2007. From 1981 to 1989, she was with Lincoln Laboratory, Massachusetts Institute of Technology. She received her Sc.B. degree from Brown University, and M.Sc. and Ph.D. degrees from Princeton University.
Dr. Pang's research interests include nanofabrication technology for microelectromechanical, biomedical, microelectronic, and optical devices. She has over 400 technical papers, book chapters, and invited presentations and is the editor and author of 16 books, journals and conference proceedings. Dr. Pang has 9 patents granted in nanotechnology and microsystems. She has taught 32 short courses on microfabrication and nanoimprint technology for microelectronic manufacturing and microelectromechanical systems. She is a Fellow of IEEE, ECS, and AVS.
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