Nanonization procedures of active pharmaceutical ingredients containing innovative technologies

Modern pharmaceutical technology is concentrated on formulations which are targeted to the exact site at the appropriate time, with maximum efficiency and with reduced side-effects. Nanoparticle engineering has been developed and reported for pharmaceutical applications. In this approach, poorly water-soluble compounds are formulated as nanometer-sized (100-1000 nm) drug particles, offering increased bioavailability, improved absorption, and the potential for drug targeting. Therefore we should find cost-effective production by new technological processes containing the most important technological and material parameters.

The various methods used to decrease particle size into the micro- or the nanosize range can be divided into two main categories: as bottom-up and top-down techniques. In this approach, poorly water-soluble compounds are formulated as nanometer-sized drug particles (nonsteorid anti-inflammatory agents, antibiotics and pharmacons effect the central nervous system). We have applied as bottom-up methods the melt emulsification, solvent diffusion and solvent evaporation techniques using different drugs. We also apply technological procedures as co-milling, high pressure homogenization, high intensity ultrasound, solvent-antisolvent precipitation, nano-spray-drying, freeze-drying, coating. The micrometric and physicochemical properties, structure, compatibility, stability, in vitro, ex vivo, in silico and in vivo evaluations are used. By using nanoparticles in nasal/pulmonar formulation (alternative drug administration), innovative and more efficient products can be achieved, which may lead to the improvement of different therapies.

ACKNOWLEDGEMENT: Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged.

BIO:

Rita Ambrus is an Associate Professor in Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged. Professor Ambrus is also an experimental leader of Nanotechnological Reserch group of Inderdisciplinary Excellence Centre University of Szeged. In her research group development of technological procedure and alternative drug administration could be found to reach improved bioavailability of poorly water-soluble drugs.