The mechanics of early human development

This PhD project aims to delve into the complex mechanisms of mechanobiology and their crucial influence on human embryo development. A growing body of evidence suggests that mechanical forces, alongside biochemical signals, play a significant role in cellular function and organismal development. However, the specific interactions and effects of these forces during the early stages of human development remain largely unexplored due to technical and ethical limitations. This research seeks to bridge this gap by employing state-of-the-art techniques in biomechanics, developmental biology, and computational modeling to examine how mechanobiological forces guide cell differentiation, tissue morphogenesis, and organ development during the first weeks of pregnancy.

The study will focus on three primary objectives: (1) To measure and analyze the mechanical forces exerted on cells in the developing embryo, (2) to assess how these forces influence signaling pathways and gene expression related to cell fate decisions, and (3) to determine the implications of aberrant mechanical forces on developmental anomalies in both embryonic and extraembryonic tissues

The project will utilize advanced microfabricated devices capable of simulating the mechanical environment of the womb. These devices will house cells and be subjected to controlled mechanical stimuli, mimicking the natural stresses and strains experienced during early embryogenesis. Live cell imaging techniques will allow for real-time observation and quantification of mechanical forces at play.

Simultaneously, cutting-edge genetic sequencing technologies will monitor changes in gene expression in response to different mechanical conditions. By integrating these data, the project intends to construct a detailed map of the mechanotransduction pathways that are active during early development.

By focusing on a largely underexploited yet critical area of embryonic development, this research is expected to provide groundbreaking insights into the role of mechanobiological forces in human embryo development. Understanding these interactions will not only refine our fundamental knowledge of developmental biology but could lead to improved clinical protocols in assisted reproduction technologies (ART) and potentially pave the way for novel interventions for developmental disorders.

Further information

Location and skills

The project will be carried out at the Institute for Bioengineering (IBioE) at the University of Edinburgh. The student will attain skills in mammalian cell culture, embryo models, microfluidics, materials, optical microscopy, as well as data and image analysis.

Career development

Institutional and Peer Support: you will benefit from an excellent supportive environment at the School of Engineering within the Institute for Bioengineering at The University of Edinburgh.

International Collaboration: the successful student will also have to opportunity visit and interact with our network of international collaborators.

Impactful publications and dissemination: the student will also benefit from strong support towards publications in world class journals and participation in major conferences as well as support to undertake outreach to the wider public.

Teaching and Research Development: the potential student will have the opportunity (once trained and familiar with relevant materials) to become a teaching assistant for courses offered at the School of Engineering.

The University of Edinburgh is committed to equality of opportunity for all its staff and students, and promotes a culture of inclusivity: https://www.ed.ac.uk/equality-diversity

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Principal Supervisor

Eligibility

Minimum entry qualification - an Honours degree at 2:1 or above (or International equivalent) in a relevant science or engineering discipline, possibly supported by an MSc Degree. Further information on English language requirements for EU/Overseas applicants.

Funding

We welcome applications from self-funded students

Further information and other funding options.

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